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Drug ReportsCyproterone acetate
Cyproterone acetate
Cyproterone acetate is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against androgen receptor.
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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dianeal low calcium peritoneal dialysis solution with dextrose dianeal pd-2 peritoneal dialysis solution with dextroseNew Drug Application2013-06-30
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Indications
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Clinical
Clinical Trials
64 clinical trials
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Indications Phases 4
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
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Other
Total
Non-small-cell lung carcinomaD002289——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCyproterone acetate
INN_
Description
Cyproterone acetate is a steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas. It has a role as an androgen antagonist, a progestin and a geroprotector. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid, a chlorinated steroid, a steroid ester and an acetate ester. It is functionally related to a cyproterone.
Classification
Small molecule
Drug classantiandrogens
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C
Identifiers
PDB—
CAS-ID427-51-0
RxCUI—
ChEMBL IDCHEMBL139835
ChEBI ID50743
PubChem CID9880
DrugBankDB04839
UNII ID4KM2BN5JHF (ChemIDplus, GSRS)
Target
Agency Approved
AR
AR
Organism
Homo sapiens
Gene name
AR
Gene synonyms
DHTR, NR3C4
NCBI Gene ID
367
Protein name
androgen receptor
Protein synonyms
Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Uniprot ID
Q9UD95
Mouse ortholog
Ar (11835)
androgen receptor (P19091)
Alternate
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Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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148,265 adverse events reported
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